Elevated Numbers of Fc RIIIA (CD16 ) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

نویسندگان

  • Hans-Gustaf Ljunggren
  • Carl Jorns
  • Bo-Göran Ericzon
  • Ola Weiland
  • Johan K. Malmberg
  • Karolin Falconer
  • Annette Alaeus
  • Greg Nowak
  • Niklas K. Björkström
  • Veronica D. Gonzalez
  • Karl-Johan Malmberg
  • Johan K. Sandberg
چکیده

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Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection.

CTL are crucial in the defense against viral infections. In the course of investigating peripheral blood and intrahepatic CD8 T cells in patients with chronic hepatitis C virus (HCV) infection, we observed a significant population of CD8 T cells expressing the FcgammaRIIIA (CD16) receptor. This observation led us to characterize these cells with respect to their phenotype and function in a coho...

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The transmembrane receptor for immunoglobulin G immune complexes on natural killer (NK) cells and macrophages, Fc gamma RIIIA (CD16), mediates cellular activation through a tyrosine kinase-dependent pathway. We show that Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells and demonstrate a physical association of p56lck with Fc gamma RIIIA in immunoprec...

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تاریخ انتشار 2008